Preferred Label : Monoclonal Antibody NEO-201;
NCIt synonyms : h16C3; h16C3 Antibody; Neoantigen-targeting Antibody NEO-201;
NCIt related terms : NEO-201;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody derived from an immunogenic
preparation of tumor-associated antigens (TAAs) from pooled allogeneic colon cancer
tissue extracts, with potential antineoplastic and immunomodulatory activities. Upon
intravenous administration, monoclonal antibody NEO-201 targets and binds to malignant
tissues with tumor-specific mutations in the membrane-anchored proteins, carcinoembryonic
antigen-related cell adhesion molecules 5 and 6 (CEACAM5 and CEACAM6). This prevents
the interaction between tumor cell CEACAM 5 and natural killer (NK) cell CEACAM1,
and reverses CEACAM1-dependent inhibition of NK cytotoxicity. This may result in the
activation of NKs and results in NK-mediated tumor cell killing. Additionally, monoclonal
antibody NEO-201 may activate innate immune responses against tumor cells such as
antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity
(CDC). CEACAM 5, and 6 are members of the CEA family of proteins. These membrane proteins
are over expressed in a variety of cancer cell types and play a key role in cell migration,
invasion, and adhesion.;
UNII : 41E6FO0DX2;
Molecule name : NEO-201; NEO 201;
NCI Metathesaurus CUI : CL563093;
Origin ID : C156398;
UMLS CUI : C4744794;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
