Preferred Label : Histone H3 Lysine 79;
NCIt synonyms : Histone H3 Lys79; Lysine 79 of Histone H3; H3K79; Histone H3 Lysine 80; Histone H3 Lys80;
NCIt definition : The lysine residue found at amino acid position 79 in the histone H3 protein. Methylation
of this residue by DOT1L protein disrupts telomeric silencing and may be a marker
for cellular transformation and disease progression in patients with leukemia.;
NCIt note : Even though the literature refers to lysine 79 methylation/other modification or amino
acid variation/mutation, RefSeq indicates that the lysine is located at amino acid
position 80 in histone H3. (see also https://link.springer.com/article/10.1007/s00401-018-1867-2);
NCI Metathesaurus CUI : CL563077;
PubMed : 27234562;
Origin ID : C156388;
UMLS CUI : C4744788;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
