Dexverapamil - CISMeF

Preferred Label : Dexverapamil;

NCIt synonyms : R Verapamil; R-Verapamil;

NCIt definition : The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04);

UNII : QR5PYD126V;

InChIKey : SGTNSNPWRIOYBX-HHHXNRCGSA-N;

CAS number : 38321-02-7;

Chemical formula : C27H38N2O4;

Details

Origin ID

C1563;

UMLS CUI

C0280858;

Automatic exact mappings (from CISMeF team)
- verapamil [MeSH Descriptor]
Currated CISMeF NLP mapping
- dexverapamil [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dexverapamil [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cyclophosphamide/Dexverapamil/Doxorubicin/Etoposide/Prednisolone/Vincristine [NCIt concept]
- Cyclophosphamide/Dexverapamil/Doxorubicin/Etoposide/Prednisone/Vincristine [NCIt concept]
- Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine/R-Verapamil [NCIt concept]
- Cytarabine/Dexverapamil/Etoposide/Idarubicin [NCIt concept]
- Dexverapamil/Doxorubicin [NCIt concept]
- Dexverapamil/Paclitaxel [NCIt concept]
- Dexverapamil/Vinblastine [NCIt concept]

Keyword's position in hierarchy(ies) :

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