Preferred Label : Alkylglycerol/Rosemary Capsules;
NCIt synonyms : Rosemary/Alkylglycerol Dietary Supplement; Alkylglycerol and Rosemary Capsules;
NCIt definition : An orally available capsule containing alkylglycerols and Rosmarinus officinalis extracts
standardized to diterpenes, including carnosic acid and carnosol, with potential antineoplastic
and anti-inflammatory activities. Upon administration, carnosic acid and carnosol
may induce apoptosis by decreasing apoptosis regulator B-cell lymphoma 2 (Bcl-2) expression,
decrease tumor cell growth through inhibition of mammalian target of rapamycin (mTOR)
phosphorylation, and inhibit metastatic activity by preventing the adhesion of tumor
cells to type I collagen and fibronectin. Additionally, these diterpenes may decrease
inflammation by downregulating cyclooxygenase (COX) type 2 (COX-2) protein synthesis.
Alkylglycerols (alkyl-Gro) are bioactive ether lipids that may, through a not yet
fully elucidated mechanism, inhibit tumor cell growth and metastases.;
NCI Metathesaurus CUI : CL563027;
Origin ID : C156175;
UMLS CUI : C4744622;
Semantic type(s)
- concept_is_in_subset
