Preferred Label : Vulinacimab;
NCIt synonyms : Anti-VEGFR2 Monoclonal Antibody HLX06;
NCIt definition : A fully human monoclonal antibody directed against human vascular endothelial growth
factor receptor 2 (VEGFR-2) with potential anti-angiogenesis and antineoplastic activities.
Upon administration, vulinacimab specifically binds to and inhibits VEGFR-2, which
may inhibit tumor angiogenesis and tumor cell proliferation. VEGFR-2, a tyrosine-protein
kinase that plays an essential role in angiogenesis and the proliferation, survival,
migration and differentiation of endothelial cells, is overexpressed in certain tumor
types.;
UNII : SA09JNQ24D;
CAS number : 2250342-36-8;
Molecule name : HLX-06; HLX 06;
NCI Metathesaurus CUI : CL563001;
Origin ID : C156172;
UMLS CUI : C5418256;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
