Preferred Label : Cisplatin Transmucosal Patch;
NCIt synonyms : Cisplatin Transmucosal System; Cisplatin Drug-loaded Patch;
NCIt definition : A transmucosal patch containing cisplatin, an inorganic platinum agent, with potential
antineoplastic activity. Upon mucosal application to the tumor site in the oral cavity,
and upon subsequent release from the patch, cisplatin forms highly reactive, charged,
platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA
inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links.
These cross-links result in apoptosis and growth inhibition of tumor cells.;
Molecule name : PRV-111; PRV 111;
NCI Metathesaurus CUI : CL562866;
Origin ID : C156155;
UMLS CUI : C4733683;
Semantic type(s)
- concept_is_in_subset
