Preferred Label : Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor;
Obsolete resource : true;
NCIt synonyms : rEV576; Recombinant Ornithodoros moubata Complement Inhibitor; Recombinant EV576; Recombinant OmCI; Complement C5-inhibitor rEV576;
NCIt definition : A recombinant small peptide inhibitor of the terminal complement pathway protein C5
originally derived from a protein in the saliva of the Ornithodoros moubata tick,
with potential anti-inflammatory and cytoprotective activities. Upon administration,
recombinant Ornithodoros moubata saliva-derived small protein complement C5 inhibitor
targets and binds to a unique site on the terminal complement protein C5, which blocks
C5 cleavage into the pro-inflammatory components C5a and C5b, and prevents the C5b-dependent
assembly of the membrane-attack complex (MAC; C5b-9). This prevents MAC-mediated lysis
and destruction of red blood cells (RBCs) in paroxysmal nocturnal hemoglobinuria (PNH)
and prevents tissue destruction in various other complement-mediated inflammatory
and autoimmune diseases. In addition, this C5 inhibitor targets, binds to and inhibits
the activity of leukotriene B4 (LTB4), thereby further preventing inflammatory-mediated
cell destruction.;
NCIt note : See 'Nomacopan(C167012)';
Concept status : Retired_Concept;
Drug name : Coversin;
NCI Metathesaurus CUI : CL562865;
Origin ID : C156154;
UMLS CUI : C4733681;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
