Preferred Label : Autologous B-cell/Monocyte-presenting HER2/neu Antigen Vaccine BVAC-B;
NCIt synonyms : HER2/neu-specific Autologous B-cell/Monocyte Vaccine BVAC-B;
NCIt definition : An autologous vaccine composed of the antigen presenting cells (APCs) B-lymphocytes
and monocytes presenting the tumor-associated antigen (TAA) human epidermal growth
factor receptor type 2 (HER2/neu; HER-2; EGFR2; ErbB2). Upon administration of the
autologous B-cell- and monocyte-presenting HER2/neu antigen vaccine BVAC-B, the APCs
may stimulate the immune system to mount a HER2/neu-specific cytotoxic T-lymphocyte
(CTL) immune response as well as a natural killer (NK) cell, and antibody-mediated
immune response against HER-2/neu-positive tumor cells, which may result in tumor
cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal
growth factor (EGF), is overexpressed by a variety of tumors.;
Molecule name : BVAC B; BVAC-B;
NCI Metathesaurus CUI : CL562872;
Origin ID : C156153;
UMLS CUI : C4733680;
Semantic type(s)
- concept_is_in_subset
