Preferred Label : Anti-VEGF Monoclonal Antibody hPV19;
NCIt synonyms : MoAb hPV19; Anti-VEGF MAb hPV19;
NCIt definition : A humanized monoclonal antibody directed against human vascular endothelial growth
factor (VEGF), with potential anti-angiogenic and antineoplastic activities. Upon
administration, anti-VEGF monoclonal antibody hPV19 targets and binds to VEGFR at
a unique binding site and inhibits VEGF binding to its receptors, VEGFR1 and VEGFR2,
thereby preventing VEGF/VEGFR-mediated signaling. This prevents the growth and maintenance
of tumor blood vessels. This decreases nutrient supply to tumor cells, resulting in
tumor cell death. Increased VEGF/VEGFR signaling is associated with increased invasiveness
and decreased survival.;
Molecule name : hPV 19; hPV-19;
NCI Metathesaurus CUI : CL562852;
Origin ID : C156139;
UMLS CUI : C4733677;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
