Monoclonal Antibody Lym-1

Preferred Label : Monoclonal Antibody Lym-1;

NCIt synonyms : Lym-1; Monoclonal Antibody Lym-1, IgG2a Murine; IgG2a murine monoclonal antibody Lym-1; MoAb Lym-1;

NCIt definition : A murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells. When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils. (NCI04);

NSC code : 620858;

Codes from synonyms : NSC0620858;

Details

Origin ID

C1561;

UMLS CUI

C0280726;

Currated CISMeF NLP mapping
- Lym-1 monoclonal antibody [MeSH concept]
- Lym-1 monoclonal antibody [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lym-1 monoclonal antibody [MeSH concept]
- Lym-1 monoclonal antibody [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Interleukin-2/Monoclonal Antibody Lym-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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