Preferred Label : Autologous CMV-pp65-flLAMP mRNA Loaded Dendritic Cell Vaccine;
NCIt synonyms : Autologous flLAMP-pp65-DCs; Autologous flLAMP-pp65 mRNA-pulsed DC Vaccine; Autologous pp65-flLAMP DC Vaccine; Autologous CMV pp65-LAMP mRNA-loaded DC Vaccine; Autologous CMV-pp65-flLamp DCs; Autologous pp65-flLAMP DCs; Autologous flLAMP-pp65-DC Vaccine;
NCIt definition : A cancer cell vaccine consisting of autologous dendritic cells (DCs) loaded with mRNA
encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix
phosphoprotein; UL83) as a fusion protein with the full-length lysosome-associated
membrane protein (flLAMP), with potential immunostimulatory and antineoplastic activities.
Upon vaccination, the autologous CMV-pp65-flLAMP mRNA loaded DC vaccine exposes the
immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL)
response against CMV pp65-expressing tumor cells. The incorporation of flLAMP may
route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC
class II antigen presentation, thereby promoting CD4-positive T-cell responses. The
CMV pp65 protein is the primary component of the enveloped subviral particle of CMV
and is expressed in certain tumor types.;
NCI Metathesaurus CUI : CL562918;
Origin ID : C156067;
UMLS CUI : C4744546;
Semantic type(s)
- concept_is_in_subset
- has_target
