" /> BCMA x CD3 T-cell Engaging Antibody CC-93269 - CISMeF





Preferred Label : BCMA x CD3 T-cell Engaging Antibody CC-93269;

NCIt synonyms : BCMAxCD3 TCB CC-93269; BCMAxCD3 BiTE Antibody CC-93269; BCMA x CD3 T Cell Engaging Antibody CC-93269; BCMA/CD3-directed Bispecific T-cell Engager Antibody CC-93269; Anti-BCMA/CD3 Bispecific Antibody CC-93269; Bi-specific Antibody CC-93269; BCMA/CD3 T-cell Bi-specific Antibody CC-93269;

NCIt definition : A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-BCMA/CD3 T-cell engaging antibody CC-93269, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.;

Molecule name : CC-93269; EM901; CC 93269;

NCI Metathesaurus CUI : CL562897;

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12/05/2024


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