Preferred Label : Zirconium Zr 89 DFO-Daratumumab;
NCIt synonyms : Zr 89-DFO-Daratumumab; (89)Zr-Daratumumab; 89Zr-DFO-Daratumumab;
NCIt related terms : DARATUMUMAB-DFO ZR-89;
NCIt definition : A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k)
monoclonal antibody directed against the cell surface glycoprotein CD38, and linked,
via the chelator desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89),
with potential diagnostic properties upon positron emission tomography (PET) imaging.
Upon administration, the monoclonal antibody moiety of zirconium Zr 89-DFO-daratumumab
specifically targets and binds to cell surface antigen CD38. Upon binding, the radioisotope
moiety may be detected using PET, thereby allowing the imaging and quantification
of CD38-expressing tumor cells. CD38, a cell surface glycoprotein, is expressed on
various hematopoietic cells and is overexpressed on multiple myeloma (MM) cells.;
UNII : BF2SMF4KKT;
NCI Metathesaurus CUI : CL562756;
Origin ID : C156021;
UMLS CUI : C4744512;
Semantic type(s)
- concept_is_in_subset
- has_target
