Preferred Label : Hormone Replacement Therapy;
NCIt synonyms : Hormone Replacement Rx; HRT;
NCIt related terms : hormone replacement therapy type; menopausal hormone therapy; hormone_replacement_therapy_type;
NCIt definition : Treatment with estrogens or estrogen/progesterone after menopause or ovariectomy to
prevent pathological effects of decreased estrogen production.;
Alternative definition : NCI-GLOSS: Hormones (estrogen, progesterone, or both) given to women after menopause
to replace the hormones no longer produced by the ovaries.;
NCIt note : In women, treatment with sex hormones is indicated for a number of reasons, including
menopause, partial or full hysterectomy, or amenorrhea. NHLBI of NIH stopped early
a major clinical trial of the risks and benefits of combined estrogen and progestin
in healthy menopausal women due to an increased risk of invasive breast cancer and
lack of overall benefit. Though with fewer cases of hip fractures and colon cancer,
combined estrogen and progestin leads to an increased risk of invasive breast cancer,
coronary heart disease, stroke, and pulmonary embolism in healthy menopausal women
on estrogen plus progestin compared to those taking placebo pills. However, a separate
study of estrogen alone in women who had a hysterectomy before receiving therapy continues
unchanged because, at this point, the balance of risks and benefits of estrogen alone
is still uncertain. (http://www.nhlbi.nih.gov/new/press/02-07-09.htm and NCI);
Codes from synonyms : CDR0000046127; CDR0000304725; CDR0000044412;
Origin ID : C15599;
UMLS CUI : C0282402;
Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
