Preferred Label : Defibrotide (Bovine);
NCIt definition : A mixture of single-stranded oligodeoxyribonucleotides derived from bovine pulmonary
tissue, with anti-thrombotic, thrombolytic, and fibrinolytic activities. Upon administration,
and although the exact mechanism of action has yet to be fully elucidated, defibrotide
induces the release of prostaglandin I2 (PGI2), E2 (PGE2), and prostacyclin and reduces
the expression of adhesion molecules on endothelial cells. This relaxes the smooth
muscle of blood vessels and prevents platelets from adhering to each other and to
the endothelium. This protects the endothelium lining bloods vessels. Defibrotide
increases tissue plasminogen activator (t-PA) and decreases plasminogen activator
inhibitor-1 activity. This increases the activity of plasmin, prevents blood clot
formation and dissolves blood clots.;
UNII : 438HCF2X0M;
CAS number : 83712-60-1;
NCI Metathesaurus CUI : CL562732;
Origin ID : C155982;
UMLS CUI : C4083210;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
