Preferred Label : Fluorine F 18-AIF-NOTA-neurotensin;
NCIt synonyms : 18F-aluminum Fluoride-1,4,7-triazacyclononane-1,4,7-triacetic Acid-neurotensin; 18F-AlF-NOTA-neurotensin; [18F]Aluminum Fluoride-1,4,7-triazacyclononane-1,4,7-triacetic Acid-neurotensin; Fluorine F 18-Al-NOTA-neurotensin; [18F]AlF-NOTA-neurotensin; 18F-AlF-NOTA-NT;
NCIt definition : A radioconjugate containing neurotensin (NT) linked to the radionuclide fluorine F
18 (18F), by the macrocyclic chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA), through a method that first couples 18F to aluminum (Al), with potential
use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT).
Upon administration of fluorine F 18-Al-NOTA-neurotensin, the ligand moiety targets
and binds to the neurotensin receptor (NTR). Upon PET/CT, NTR-expressing tumor cells
can then be visualized and NTR tumor cell expression can be assessed, as well as the
diagnosis and stage of cancer. The neuropeptide NT is overexpressed in certain types
of cancers and plays a key role in tumor cell proliferation.;
NCI Metathesaurus CUI : CL562717;
Origin ID : C155972;
UMLS CUI : C4733663;
Semantic type(s)
- concept_is_in_subset
