Preferred Label : MEK inhibitor CS3006;
NCIt synonyms : MAPK Kinase Inhibitor CS3006;
NCIt definition : An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase
kinase (MAP2K; MAPKK; MEK), with potential antineoplastic activity. Upon oral administration,
MEK inhibitor CS3006 specifically targets, binds to and inhibits the catalytic activity
of MEK, thereby inhibiting the activation of MEK-dependent effector proteins including
extracellular signal-regulated kinase (ERK) and inhibits the proliferation of tumor
cells in which the RAS/RAF/MEK/ERK signaling pathway is overactivated. The threonine/tyrosine
protein kinase MEK plays a key role in the RAS/RAF/MEK/ERK signaling pathway, which
is frequently upregulated in a variety of tumor cell types. The RAS/RAF/MEK/ERK pathway
regulates key cellular activities including cell growth, proliferation, survival,
differentiation and apoptosis.;
Molecule name : CS-3006; CS 3006;
NCI Metathesaurus CUI : CL562716;
Origin ID : C155971;
UMLS CUI : C4733662;
Semantic type(s)
- concept_is_in_subset
