Preferred Label : Anti-CD33/CD3 Bispecific Antibody GEM 333;
NCIt synonyms : Anti-CD33/CD3 Antibody GEM 333; Anti-CD33/Anti-CD3 Bispecific Antibody GEM 333; Anti-CD33 Bispecific Antibody GEM 333;
NCIt definition : A bispecific antibody possessing two antigen-recognition and binding sites, one for
the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell
receptor (TCR), and one for the tumor-associated antigen (TAA) CD33, with potential
immunostimulating and antineoplastic activities. Upon administration of anti-CD33/CD3
bispecific antibody GEM 333, this bispecific antibody binds to both the CD3 antigen
on cytotoxic T-lymphocytes (CTLs) and the CD33 antigen found on CD33-expressing tumor
cells, thereby crosslinking tumor cells and CTLs. This activates and redirects CTLs
to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing
tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent
hematopoietic stem and progenitor cells (HSPCs) and is overexpressed on a variety
of cancer cell types, including acute myeloid leukemia (AML). It plays a key role
in tumor initiation, proliferation and progression.;
Molecule name : GEM-333; GEM 333;
NCI Metathesaurus CUI : CL562715;
Origin ID : C155970;
UMLS CUI : C4733661;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
