Preferred Label : Carbon C 14 Mivavotinib Citrate;
NCIt synonyms : [14C]TAK 659; [14C]TAK-659; 14C-labeled Mivavotinib Citrate; [14 C]-TAK-659;
NCIt definition : A radioconjugate composed of the citrate form of mivavotinib, an orally bioavailable
selective inhibitor of the non-receptor tyrosine kinase (RTK) spleen tyrosine kinase
(Syk), labeled with the radioisotope carbon C 14, with potential use for evaluating
the pharmacokinetic profile of mivavotinin. Upon administration of carbon C 14 mivavotinib
citrate, mivavotinib targets, binds to and inhibits Syk. Labeling of mivavotinib with
the radioactive tracer carbon C 14 permits the evaluation of this agent's pharmacokinetic
profile, including its absorption, distribution, metabolism, and excretion (ADME).
Syk, a B-cell receptor (BCR)-associated non-receptor tyrosine kinase that mediates
B-cell activation, chemotaxis, adhesion and proliferation, is expressed in hematopoietic
tissues and is often overexpressed in hematopoietic malignancies.;
NCI Metathesaurus CUI : CL562721;
Origin ID : C155968;
UMLS CUI : C5908080;
Semantic type(s)
- concept_is_in_subset
