Preferred Label : Fosmanogepix;
NCIt synonyms : Prodrug APX001; Pyridinium, 2-amino-1-((phosphonooxy)methyl)-3-(3-((4-((2-pyridinyloxy)methyl)phenyl)methyl)-5-isoxazolyl)-,
inner salt; (12-Amino-6-oxa-1(3),7(2)-dipyridina-2(5,3)-(1,2)oxazola- 4(1,4)-benzenaheptaphan-11-ium-11-yl)methyl
hydrogen phosphate;
NCIt definition : An orally available small molecule inhibitor of the Gwt1 fungal enzyme with potential
antifungal activity. Upon administration, fosmanogepix, a N-phosphonooxymethyl prodrug,
is rapidly and completely metabolized by systemic alkaline phosphatases to its active
moiety, APX001A (E1210). The active prodrug targets Gwt1, a highly conserved inositol
acylase which catalyzes an essential step in the glycosylphosphatidylinositol (GPI)-anchor
biosynthesis pathway. Inhibition of Gwt1 prevents localization of cell wall mannoproteins,
which compromises cell wall integrity, biofilm formation, germ tube formation, and
fungal growth.;
UNII : 1XQ871489P;
InChIKey : JQONJQKKVAHONF-UHFFFAOYSA-N;
CAS number : 2091769-17-2;
Molecule name : E1211; APX-001;
NCI Metathesaurus CUI : CL562775;
Origin ID : C155900;
UMLS CUI : C5139854;
Semantic type(s)
- concept_is_in_subset
