Preferred Label : Gallium Ga 68-NOTA-anti-HER2 Nanobody VHH1;
NCIt synonyms : 68Ga-NOTA-2Rs15d; 68Ga-NOTA-anti-HER2 VHH1; Gallium Ga 68-NOTA-anti-HER2-VHH1; 68Ga-HER2-Nanobody VHH1;
NCIt definition : A radioconjugate composed of a nanobody directed against human epidermal growth factor
receptor 2 (HER2, EGFR2, ERBB2) that is linked, through the macrocyclic chelating
agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the radionuclide gallium
(Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed
tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-anti-HER2 Nanobody
VHH1, the anti-HER2 antibody moiety targets and binds to HER2-expressing cells. This
facilitates both detection of HER2-expressing tumor cells and assessment of responses
to HER2-targeted chemotherapeutic agents during PET/CT. HER2, a tyrosine kinase is
overexpressed on the cell surfaces of various tumor cell types.;
Molecule name : VHH1;
NCI Metathesaurus CUI : CL562773;
Origin ID : C155898;
UMLS CUI : C4733648;
Semantic type(s)
- concept_is_in_subset
