NCIt definition : A recombinant, human-mouse chimeric monoclonal antibody directed against the epidermal
growth factor receptor (EGFR) with potential antineoplastic activity. Upon intravenous
administration, anti-EGFR monoclonal antibody CPGJ 602 targets and binds to EGFR,
which prevents receptor dimerization and activation. This leads to an inhibition of
EGFR-dependent downstream pathways and EGFR-dependent tumor cell proliferation and
metastasis. EGFR, a receptor tyrosine kinase, may be overexpressed on the surfaces
of various tumor cell types.;
Semantic type(s)