NCIt definition : An orally bioavailable inhibitor of the tyrosine kinase Janus kinase 1 (JAK1), with
potential anti-inflammatory and immunomodulating activities. Upon oral administration,
filgotinib specifically targets, binds to, and inhibits the phosphorylation of JAK1,
which interferes with JAK/STAT (signal transducer and activator of transcription)-dependent
signaling. As JAK1 mediates signaling of many pro-inflammatory cytokines, JAK1 inhibition
prevents cytokine signaling and activity in many inflammatory and immune-mediated
processes and leads to a decrease in inflammation and activation of certain immune
cells. JAK1 plays a key role in the signaling and activity of many cytokines and growth
factors and is often dysregulated in a variety of autoimmune and inflammatory diseases,
as well as some malignancies.;
UNII : 3XVL385Q0M;
InChIKey : RIJLVEAXPNLDTC-UHFFFAOYSA-N;
CAS number : 1206161-97-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1206161-97-8
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