Preferred Label : Samuraciclib;
NCIt synonyms : CDK7 Inhibitor CT7001;
NCIt definition : An orally available, selective inhibitor of cyclin-dependent kinase 7 (CDK7) with
potential antineoplastic activity. Upon oral administration, samuraciclib selectively
and competitively binds to the CDK7 ATP binding site, thereby inhibiting CDK7-mediated
signaling. CDK7, a serine/threonine kinase, plays a role in controlling cell cycle
progression, transcriptional regulation, and promotes the expression of key oncogenes
such as c-Myc through the phosphorylation of RNA polymerase II. Inhibition of CDK7
may inhibit tumor cell proliferation in certain cancers that are dependent on CDK7-mediated
transcriptional regulation and signaling.;
UNII : 46D4HS9ODA;
InChIKey : YCVGLKWJKIKVBI-MJGOQNOKSA-N;
CAS number : 1805833-75-3;
Molecule name : CT-7001; CT 7001;
NCI Metathesaurus CUI : CL556268;
Origin ID : C155652;
UMLS CUI : C5418252;
Semantic type(s)
- concept_is_in_subset
