Preferred Label : BR96 sFv-PE40;
NCIt definition : A single-chain immunotoxin consisting of Fv fragments of the BR96 monoclonal antibody
(MoAb) and a truncated Pseudomonas exotoxin (PE40) that lacking the binding domain.
MoAb BR96 specifically binds to Lewis Y-related carbohydrate antigen, a cell surface
antigen overexpressed in many carcinomas. After internalization, PE40 causes ADP-ribosylation
of transcription elongation factor 2, thereby inactivating elongation factor 2 and
inhibiting protein synthesis in the cancer cells.;
Molecule name : SGN-10;
Origin ID : C1549;
UMLS CUI : C0259637;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
