Preferred Label : Clostridium butyricum CBM 588 Probiotic Strain;
NCIt synonyms : C. butyricum Strain MIYAIRI 588; Clostridium butyricum MIYAIRI 588; C. butyricum MIYAIRI Strain; MIYAIRI 588 Strain of C. butyricum; C. butyricum CBM 588 Probiotic Strain; Clostridium butyricum MIYAIRI 588 Probiotic Strain;
NCIt related terms : CLOSTRIDIUM BUTYRICUM MIYAIRI 588 STRAIN;
NCIt definition : A probiotic containing a specific strain of the anaerobic, butyric acid-forming Gram-positive
bacterium Clostridium butyricum (C. butyricum), with potential immunomodulatory, anti-inflammatory
and antineoplastic activities. Clostridium butyricum MIYAIRI (CBM) 588 is the 588th
MIYAIRI strain, isolated from a soil sample in Japan in 1963. Upon oral administration
of C. butyricum CBM 588 probiotic strain, C. butyricum modulates the composition of
the normal gastrointestinal (GI) microflora, by increasing the beneficial bacteria
and decreasing the harmful bacteria, and helps maintain adequate colonization of the
GI tract, thereby improving digestion and preventing GI disturbances. These bacteria
and the butyric acid produced by them create an environment unfavorable to pathogens
by adhering to human epithelial cells and forming a protective mucosal barrier. This
prevents attachment of pathogens and reduces the risk of infection. By restoring gut
microbiota, these bacteria may restore or enhance intestinal immune responses. C.
butyricum induces interleukin-10-producing macrophages in inflamed mucosa via the
Toll-like receptor 2 (TLR2)/myeloid differentiation primary response gene 88 (MyD88)
pathway, thereby decreasing inflammatory responses. In addition, CBM588 may exert
antineoplastic activity by inducing the release of the endogenous cytokine tumor necrosis
factor-related apoptosis-inducing ligand (TRAIL) from intracellular stores in polymorphonuclear
neutrophils (PMNs), most likely involving matrix metalloproteinase 8 (MMP-8) and the
Toll-like receptors (TLR)2/4 signaling pathways. This results in TRAIL-mediated induction
of apoptosis in susceptible tumor cells.;
UNII : D3C7ZS6A9F;
Drug name : CBM588; CBM 588; MIYAIRI 588;
NCI Metathesaurus CUI : CL555453;
Origin ID : C154674;
UMLS CUI : C4733632;
Semantic type(s)
- concept_is_in_subset
