Cryptophycin - CISMeF

Preferred Label : Cryptophycin;

NCIt synonyms : 10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone;

NCIt related terms : CRYPTOPHYCIN 1;

NCIt definition : The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI);

UNII : XO974V2M5T;

CAS number : 124689-65-2;

NSC code : 667642;

Codes from synonyms : NSC0667642; 50527;

Details

Origin ID

C1546;

UMLS CUI

C0257217;

Automatic exact mappings (from CISMeF team)
- depsipeptides [MeSH Descriptor]
Currated CISMeF NLP mapping
- cryptophycin [MeSH concept]
- cryptophycin [MeSH Supplementary Concept]
- cryptophycins [MeSH concept]
False automatic mappings
- cryptophycin 1 [MeSH concept]
- cryptophycin 1 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cryptophycin [MeSH Supplementary Concept]
- cryptophycin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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