" /> Cryptophycin - CISMeF





Preferred Label : Cryptophycin;

NCIt synonyms : 10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone;

NCIt related terms : CRYPTOPHYCIN 1;

NCIt definition : The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI);

UNII : XO974V2M5T;

CAS number : 124689-65-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 124689-65-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

NSC code : 667642;

Codes from synonyms : NSC0667642; 50527;

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15/05/2024


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