Preferred Label : Curcumin/Doxorubicin-encapsulating Nanoparticle IMX-110;
NCIt synonyms : Stat3/NF-kB/poly-tyrosine Kinase Inhibitor/Doxorubicin-encapsulating Nanoparticle
IMX-110;
NCIt definition : A water-soluble, nano-sized formulation composed of nanoparticles encapsulating the
poorly water-soluble curcumin, a signal transducer and activator of transcription
3 (Stat3), nuclear factor Kappa B (NF-kB) and poly-tyrosine kinase inhibitor (TKI),
and the antineoplastic anthracycline antibiotic doxorubicin, with potential antineoplastic
activity. Upon administration of the curcumin/doxorubicin-encapsulating nanoparticle
IMX-110, the curcumin moiety targets and inhibits the activation of STAT3 and NF-kB
and prevents STAT3- and NF-kB-mediated signaling pathways, both of which are activated
in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled
tumor cell proliferation, tumor resistance to apoptosis, metastasis and immune evasion.
The doxorubicin moiety intercalates into DNA and interferes with topoisomerase II
activity. This inhibits DNA replication and RNA synthesis, leading to tumor cell growth
inhibition and apoptosis. This agent also interacts with cell membrane lipids causing
lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration
into tumors and curcumin, by inhibiting NFkB and STAT3 activity, may circumvent the
tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant
tumor cells. Chemotherapeutic agents, such as doxorubicin, upregulate the expression
of NF-kB in tumor cells which generates chemotherapy-resistant tumor cells.;
Molecule name : IMX-110; IMX 110;
NCI Metathesaurus CUI : CL555361;
Origin ID : C154569;
UMLS CUI : C4733605;
Semantic type(s)
- concept_is_in_subset
