Preferred Label : Genetically-modified Anti-HER2-CAR-CD28zeta-expressing Allogeneic NK-92/5.28.z Cells;
NCIt synonyms : HER2.taNK Cells; NK-92/5.28.z; Anti-HER2-CAR-engineered NK-92/5.28.z Cells; Anti-HER2-CAR-CD28zeta NK-92 Cells; HER2.taNK; NK-92/5.28.z Cells;
NCIt definition : A preparation of genetically-modified natural killer (NK) cells derived from the allogeneic
NK-92 cell line that are transduced with a lentiviral vector expressing a codon-optimized
chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv)
of the anti-human epidermal growth factor 2 (HER2; ErbB2) monoclonal antibody FRP5,
and fused, via hinge and transmembrane regions, to the intracellular domain of the
costimulatory molecule CD28, and the intracellular signaling domain of the T-cell
antigen receptor complex zeta chain (CD3-zeta), with potential cytolytic, immunomodulating
and antineoplastic activities. Upon infusion of the genetically modified anti-HER2-CAR-CD28zeta-expressing
allogeneic NK-92/5.28.z cells, the NK cells recognize and bind to HER2 expressed on
tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines
and chemokines, which results in selective tumor cell lysis in HER2-expressing tumor
cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor
cell types, plays a significant role in tumor cell proliferation and tumor vascularization.
The NK-92 cells are derived from a human cytotoxic cell line composed of allogeneic,
activated, interleukin-2-(IL-2) dependent-NK cells from a 50-year old male patient
with rapidly progressive non-Hodgkin's lymphoma. As NK-92 cells are devoid of killer
inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors),
which are negative regulators of NK cell activity, cancer cells are unable to suppress
the cancer cell killing ability of the NK-92 cells.;
NCI Metathesaurus CUI : CL555364;
Origin ID : C154568;
UMLS CUI : C4733604;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
