Preferred Label : Autologous TBX-4000-treated Peripheral Blood Mononuclear Cells TBX-3400;
NCIt synonyms : TBX-3400 Cells; Autologous PBMCs TBX-3400; Autologous TBX-4000-treated Human PBMCs;
NCIt definition : An autologous cell preparation in which the autologous peripheral blood mononuclear
cells (PBMCs) are treated ex vivo with TBX-4000, a recombinant TAT-MYC fusion protein,
with potential antineoplastic and immunomodulating activities. Upon reintroduction
of the TBX-3400 cells into the patient, the generated T-cells may activate the immune
system and exert a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor
cells. The TBX-4000 recombinant fusion protein consists of the N-terminal 9 amino
acid segment of the HIV TAT protein transduction domain (PTD) fused to the MYC protein.
TBX-4000 TAT-MYC rapidly localizes to the nucleus and transiently provides signals
to drive proliferation and survival of T-cells.;
Molecule name : TBX 3400; TBX-3400;
NCI Metathesaurus CUI : CL555357;
Origin ID : C154565;
UMLS CUI : C4733602;
Semantic type(s)
- concept_is_in_subset
