Preferred Label : PD-L1/PD-L2 Peptide-Montanide Vaccine;
NCIt synonyms : PD-L1/PD-L2 Peptide Plus Montanide Vaccine; PD-L1/PD-L2 Peptide Plus Montanide ISA-51 Vaccine;
NCIt definition : A vaccine composed of peptides derived from the immune checkpoint molecules, programmed
death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2), combined with the immunoadjuvant
montanide ISA-51, with potential immunomodulating and antineoplastic activities. Vaccination
with PD-L1/PD-L2 peptide-montanide vaccine may stimulate an immune response against
PD-L1 and PD-L2 expressing cells. This may enhance T-cell proliferation, cytokine
production, and T-cell mediated cytolysis. Binding of programmed cell death protein
1 (PD-1; PDCD1; CD279) by its ligands, PD-L1 and PD-L2, results in downregulation
of T-cell responses and enhanced immune evasion. Montanide ISA-51, also known as incomplete
Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing
mineral oil with mannide oleate added as a surfactant that non-specifically stimulates
cell-mediated immune responses to antigens.;
NCI Metathesaurus CUI : CL555360;
Origin ID : C154564;
UMLS CUI : C4733617;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
