Preferred Label : PD-L2 Peptide-Montanide Vaccine;
NCIt synonyms : PD-L2 Peptide Plus Montanide Vaccine; PD-L2 Peptide Plus Montanide ISA-51 Vaccine; Programmed Death Ligand 2 Peptide Vaccine;
NCIt definition : A vaccine composed of a peptide derived from the immune checkpoint molecule programmed
death ligand 2 (PD-L2) combined with the immunoadjuvant montanide ISA-51, with potential
immunomodulating and antineoplastic activities. Vaccination with PD-L2 peptide-montanide
vaccine may mount an immune response against PD-L2 expressing cells. This may enhance
T-cell proliferation, cytokine production, and T-cell mediated cytolysis. PD-L2 binding
to its cognate receptor, programmed cell death protein 1 (PD-1; PDCD1; CD279), downregulates
T-cell responses and enhances immune evasion. Montanide ISA-51, also known as incomplete
Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing
mineral oil with mannide oleate added as a surfactant that non-specifically stimulates
cell-mediated immune responses to antigens.;
NCI Metathesaurus CUI : CL555359;
Origin ID : C154563;
UMLS CUI : C4733616;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
