Preferred Label : Gentuximab;
NCIt definition : A recombinant, humanized monoclonal antibody directed against the vascular endothelial
growth factor receptor 2 (VEGFR-2), with potential anti-angiogenic and antineoplastic
activities. Upon intravenous injection, gentuximab specifically binds to VEGFR-2,
preventing the binding of its ligand, vascular endothelial growth factor (VEGF). Inhibition
of VEGFR-2 signaling may potentially inhibit tumor angiogenesis and decrease nutrient
supply to tumor cells, resulting in tumor cell death. VEGFR-2 is a type V receptor
tyrosine kinase (RTK) expressed on endothelial cells and some tumor cells that regulates
endothelial migration and proliferation.;
NCI Metathesaurus CUI : CL555348;
Origin ID : C154552;
UMLS CUI : C4733612;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
