Recombinant Human Interleukin-15

Preferred Label : Recombinant Human Interleukin-15;

NCIt synonyms : Interleukin 15; IL15; Therapeutic Interleukin-15; rIL15; rhIL-15;

NCIt definition : A recombinant agent that is chemically identical or similar to the endogenous form of the human cytokine interleukin-15 (IL-15) with immunomodulating activity. IL-15, secreted by mononuclear phagocytes (and some other cell types) following viral infection, regulates T and natural killer cell activation and proliferation. This cytokine induces activation of transcription activators STAT3, STAT5, and STAT6 via JAK kinase signal transduction pathways in mast cells, T cells, and dendritic epidermal T cells. IL-15 and interleukin-2 (IL-2) are structurally similar and share many biological activities; both may bind to common hematopoietin receptor subunits, negatively regulating each other's activity. CD8 memory T cell number has been shown to be regulated by a balance between IL-15 and IL-2.;

UNII : VL2UPV1APW;

Details

Origin ID

C1545;

UMLS CUI

C1522569;

Automatic exact mappings (from CISMeF team)
- Interleukin 15 [OMIM gene]
- Interleukin 15 [LOINC component]
- interleukin 15 [HGNC gene]
- interleukin-15 receptor binding [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Interleukin-15 [FMA entity]
- Interleukin-15 [MeSH Descriptor]
- Interleukin-15 [MeSH concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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