Crooke Cell Tumor

Preferred Label : Crooke Cell Tumor;

NCIt synonyms : Crooke Cell Adenoma;

NCIt definition : A corticotroph pituitary tumor composed of cells with Crooke hyaline change. Ring-like cytokeratin expression is typical of these neoplasms. ACTH expression is dislocated to the cell periphery and juxtanuclear region. Ultrastructurally, intermediate filaments are arranged in a ring-like pattern. (WHO);

Neoplastic status : Undetermined;

NCI Metathesaurus CUI : CL555229;

Details

Origin ID

C154342;

UMLS CUI

C4727593;

Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Excludes anatomical site(s)
- Spinal Cord [NCIt concept]
Has associated anatomic sites
- Base of the Skull [NCIt concept]
- Central Nervous System [NCIt concept]
- Head and Neck [NCIt concept]
- Nervous System [NCIt concept]
- Pituitary Gland [NCIt concept]
- Sellar Region [NCIt concept]
- Skull [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Metastatic Lesion [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Adenohypophysial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Corticotroph Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_finding
- Crooke Hyaline Change [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_normal_cell_origin
- Adenohypophysial Cell [NCIt concept]
- Corticotroph Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
- TPIT-Lineage Adenohypophysial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Glandular Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Anterior Lobe of the Pituitary Gland [NCIt concept]
disease_mapped_to_gene
- TBX19 Gene [NCIt concept]
- USP8 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- EGFR Protein Overexpression [NCIt concept]
- USP8 Gene Mutation [NCIt concept]

Keyword's position in hierarchy(ies) :

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