Preferred Label : Coffea arabica Extract;
NCIt synonyms : Green Coffee Beans Extract; Coffee Bean Extract; Green Coffee Bean Extract;
NCIt definition : An orally bioavailable dietary supplement composed of an extract from the beans of
green coffee (Coffea arabica), which are unprocessed and unroasted, with potential
anti-inflammatory, antioxidant and chemopreventive activities. Coffea arabica extract
contain high amounts of phenolic compounds and their derivatives, such as chlorogenic
acid (CGA), and alkaloids, such as caffeine. As many of the active components in the
Coffea arabica are antioxidant compounds, upon administration, they scavenge free
radicals, protect against oxidation of low-density lipoprotein (LDL), and inhibit
cell damage due to reactive oxygen species (ROS). This inhibits oxidative stress and
protects against DNA damage. The components in the extract also inhibit enzymes involved
in inflammation, cell replication and DNA synthesis, and induce the expression of
antioxidant enzymes. They also induce anti-inflammatory-mediated pathways, decrease
nuclear factor Kappa-B (NF-kB) activation and decrease the expression of pro-inflammatory
cytokines. This may inhibit growth and induce apoptosis of cancer cells. In addition,
Coffea arabica extract upregulates the expression of anti-inflammatory adipokines
(adipocytokines), such as adiponectin, and reduces the expression of pro-inflammatory
adipokines, such as tumor necrosis factor-alpha (TNF-a), leptin and interleukin 6
(IL-6), thereby further preventing inflammation and inflammation-induced cancer. Adipokines
are normally secreted by adipose tissue and play a key role in the regulation of glucose
and fat metabolism, insulin sensitivity and inflammation.;
NCI Metathesaurus CUI : CL555290;
Origin ID : C154289;
UMLS CUI : C2684473;
Semantic type(s)
- concept_is_in_subset
