Preferred Label : Allogeneic CD19CAR-transfected Cytokine-induced Killer Cells;
NCIt synonyms : Allogeneic CARCIK-CD19 Cells; Allogeneic CARCIK-CD19 (SY); Transposon-manipulated Allogeneic CARCIK-CD19 Cells;
NCIt definition : A preparation of allogeneic cytokine-induced killer (CIK) cells derived from peripheral
blood mononuclear cells (PBMCs) transfected with the Sleeping Beauty (SB) transposon,
CD19CAR (CARCIK-CD19), with potential immunomodulatory and antineoplastic activities.
CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted,
natural killer (NK)-like T-lymphocytes. Upon infusion following an allogeneic stem
cell transplantation, the CARCIK-CD19 cells bind to CD19-expressing tumor cells, thereby
inducing selective toxicity in CD19-expressing tumor cells. CIK cells may have enhanced
cytotoxic activity compared to lymphokine-activated killer (LAK) cells. CD19 is a
B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL555285;
Origin ID : C154284;
UMLS CUI : C4727557;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
