Preferred Label : Recombinant HSA/Filgrastim Fusion Protein;
NCIt synonyms : rHSA/GCSF Fusion Protein; Human Serum Albumin GCSF; Fusion Protein rHSA/GCSF; rHSA/G-CSF;
NCIt definition : A long-acting recombinant fusion protein composed of human serum albumin (HSA) fused
to granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity.
Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds
to and activates specific cell surface receptors, thereby stimulating the proliferation,
differentiation, function, and survival of neutrophil precursors and mature neutrophils.
This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF,
prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which
further increases the half-life and bioavailability of G-CSF.;
NCI Metathesaurus CUI : CL555272;
Origin ID : C154275;
UMLS CUI : C4727548;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
