Preferred Label : mRNA-based TriMix Melanoma Vaccine ECI-006;
NCIt definition : A melanoma vaccine consisting of mRNAs encoding five different melanoma tumor-associated
antigens (TAAs) and a TriMix platform comprised of three mRNAs encoding for constitutively
activated toll-like receptor 4 (caTLR4), CD40 ligand (CD40L), and CD70, with potential
immunomodulatory and antineoplastic activities. Upon intranodal injection, mRNA based
TriMix vaccine ECI-006 may stimulate the immune system to mount both humoral and cellular
responses against tumor cells expressing the five TAAs specific to the vaccine, potentially
decreasing cellular proliferation of cells expressing these antigens. The TriMix adjuvants
CD40L and caTLR4 promote the generation of mature and active dendritic cells (DCs),
and CD70 provides a costimulatory signal to CD27 naive T-cells, thereby supporting
T-cell proliferation and inhibiting T-cell apoptosis.;
Molecule name : ECI 006; ECI-006;
NCI Metathesaurus CUI : CL555271;
Origin ID : C154274;
UMLS CUI : C4727547;
Semantic type(s)
- concept_is_in_subset
