Preferred Label : C-myb Antisense Oligonucleotide G4460;
NCIt synonyms : c-MYB Antisense Oligodeoxynucleotide; OL(1)p53; c-MYB Antisense; c-Myb Antisense OND; c-Myb LR-3001;
NCIt definition : A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene
c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460
binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript.
Suppression of c-myb expression with this agent may result in the restoration of normal
differentiation pathways, increased antiproliferative effects, and the induction of
apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress
c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation,
and inhibits apoptosis.;
Molecule name : LR-3001; INX-3001; G4460;
NSC code : 710296;
Origin ID : C1541;
UMLS CUI : C1831626;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
