Preferred Label : Platinum Acetylacetonate-Titanium Dioxide Nanoparticles;
NCIt synonyms : Sol-gel NPt Nanomaterial; Sol-gel NPt Nanoparticles; NPt Nanomaterial; NPt Nanoparticles;
NCIt definition : A preparation of platinum acetylacetonate supported by sol-gel technology functionalized
titania, with potential antineoplastic activity. Upon intravenous administration,
the platinum moiety forms complexes with nucleophilic groups such as GC-rich sites
in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein
cross-links, resulting in apoptosis and cell growth inhibition. Compared to platinum
alone, the nanoparticle formulation allows increased delivery of platinum to the tumor
site, thereby increasing efficacy while reducing systemic toxicity.;
Molecule name : NPt; NPt-Ca;
NCI Metathesaurus CUI : CL554861;
Origin ID : C153425;
UMLS CUI : C4727246;
Semantic type(s)
- concept_is_in_subset
