NCIt definition : The acetate salt form of lixumistat, an orally bioavailable biguanide compound and
mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic
activity. Upon administration, lixumistat inhibits oxidative phosphorylation, decreases
mitochondrial function, prevents tumor cell metabolism and deprives tumor cells of
energy, thereby preventing tumor cell proliferation. Mitochondrial OxPhos is overactivated
in cancer cells and plays a key role in tumor cell proliferation. Drug resistant tumor
cells are very susceptible to decreased mitochondrial OxPhos as they cannot easily
compensate for the decrease in mitochondrial function by increasing glycolysis.;
Semantic type(s)