NCIt definition : An orally available, small molecule inhibitor of the creatine transporter, solute
carrier family 6, member 8 (SLC6a8), with potential antineoplastic activity. Upon
oral administration, ompenaclid inhibits phosphocreatine uptake by SLC6a8, thereby
reducing intracellular levels of phosphocreatine available for ATP synthesis in tumor
cells. SLC6a8 is overexpressed in some cancer types and inhibition of its activity
may potentially limit tumor cell growth and metastasis.;
Semantic type(s)