Preferred Label : Pterostilbene;
NCIt synonyms : Trans-3,5-dimethoxy-4-hydroxystilbene; 3,5-Dimethoxy-4'-hydroxystilbene; Phenol, 4-(2-(3,5-Dimethoxyphenyl)ethenyl)-, (E)-; 3',5'-Dimethoxy-4-stilbenol;
NCIt definition : A naturally-derived stilbenoid structurally related to resveratrol, with potential
antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities.
Upon administration, pterostilbene exerts its anti-oxidant activity by scavenging
reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced
cell damage. It may also activate the nuclear factor erythroid 2-related factor 2
(Nrf2)-mediated pathway and increase the expression of various antioxidant enzymes,
such as superoxide dismutase (SOD). In addition, pterostilbene is able to inhibit
inflammation by reducing the expression of various inflammatory mediators, such as
interleukin (IL) 1beta, tumor necrosis factor alpha (TNF-a), inducible nitric oxide
synthase (iNOS), cyclooxygenases (COX), and nuclear factor kappa B (NF-kB). It also
inhibits or prevents the activation of many signaling pathways involved in carcinogenesis,
and increases expression of various tumor suppressor genes while decreasing expression
of certain tumor promoting genes. It also directly induces apoptosis in tumor cells.;
UNII : 26R60S6A5I;
InChIKey : VLEUZFDZJKSGMX-ONEGZZNKSA-N;
CAS number : 537-42-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 537-42-8
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G-SRS /a ;
Origin ID : C153353;
UMLS CUI : C0664965;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
