Preferred Label : Allogeneic GM-CSF-secreting Lethally Irradiated Pancreatic Tumor Cell Vaccine;
NCIt synonyms : GVAX Allogeneic Irradiated Pancreatic Tumor Cell Vaccine; Irradiated Allogeneic GM-CSF-secreting Pancreatic Tumor Cell Vaccine;
NCIt definition : An allogeneic tumor vaccine composed of lethally irradiated allogeneic pancreatic
tumor cells that are genetically modified to secrete the immunostimulatory cytokine
granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating
and antineoplastic activities. Upon intradermal injection, allogeneic GM-CSF-secreting
lethally irradiated pancreatic tumor cell vaccine secretes GM-CSF at the injection
site. In turn, GM-CSF may stimulate the body's immune system against tumor cells by
attracting and enhancing the activation of antigen-presenting cells (APCs), such as
dendritic cells (DCs). This promotes antigen presentation to T-lymphocytes and induces
a cytotoxic T-lymphocyte (CTL) response against the pancreatic tumor cells expressing
the pancreatic tumor-associated antigens (TAAs).;
NCI Metathesaurus CUI : CL554439;
Origin ID : C153334;
UMLS CUI : C4727177;
Semantic type(s)
- concept_is_in_subset
