Preferred Label : Aspacytarabine;
NCIt synonyms : Astarabine; Cytarabine Asparagine Conjugate; Ara-C Asparagine Conjugate; Asparagine Cytarabine Conjugate; Asparagine Ara-C Conjugate;
NCIt definition : A small molecule pro-drug consisting of cytarabine, an antimetabolite analog of cytidine
with a modified arabinose sugar moiety, covalently bonded to asparagine, with potential
antineoplastic activity. Upon intravenous administration, aspacytarabine targets cancer
cells, which often lack asparagine synthetase and are dependent on an external source
of amino acids due to their high metabolic rate. Once the prodrug is inside target
cells, the cytarabine component is cleaved and competes with cytidine for incorporation
into DNA. The arabinose sugar moiety of cytarabine sterically hinders the rotation
of the molecule within DNA, resulting in cell cycle arrest, specifically during the
S phase of replication. Cytarabine also inhibits DNA polymerase, resulting in a decrease
in DNA replication and repair. Because BST-236 specifically targets cancer cells,
it may spare normal tissues from cytarabine-related toxicities.;
UNII : JL7V54Z2BR;
InChIKey : PVPJTBAEAQVTPN-HRAQMCAYSA-N;
CAS number : 2098942-53-9;
Molecule name : BST 236; BST-236;
NCI Metathesaurus CUI : CL554435;
Origin ID : C153327;
UMLS CUI : C4727173;
Semantic type(s)
- concept_is_in_subset
- has_target
