Preferred Label : Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA;
NCIt synonyms : KrasG12D siRNA-loaded Mesenchymal Stromal Cells-derived Exosomes; MSC-derived Exosomes with KrasG12D siRNA;
NCIt definition : Exosomes derived from mesenchymal stromal cells (MSCs) that have been engineered to
carry short interfering RNA (siRNA) specific to the KRAS G12D mutation subtype. Upon
administration, the KRAS G12D siRNA-loaded exosomes deliver siRNA to tumor cells expressing
the mutant form of KRAS, potentially silencing its activity. The KRAS G12D mutation
is thought to drive tumorigenesis and progression in some cancers.;
NCI Metathesaurus CUI : CL554337;
Origin ID : C153214;
UMLS CUI : C4727094;
Semantic type(s)
- concept_is_in_subset
- has_target
