Dezamizumab - CISMeF

Preferred Label : Dezamizumab;

NCIt synonyms : Anti-SAP mAb; Anti-SAP Monoclonal Antibody;

NCIt definition : A fully humanized monoclonal IgG1 anti-serum amyloid P component (SAP) antibody, with potential anti-amyloid activity. Upon intravenous administration, dezamizumab binds to SAP in amyloid deposits, thereby activating compliment and triggering the rapid clearance of amyloid by macrophage-derived multinucleated giant cells. SAP is a universal component of amyloid deposits and contributes to the pathogenesis of amyloidosis.;

UNII : 6U3F28IT58;

CAS number : 1662664-56-3;

Molecule name : GSK-2398852;

NCI Metathesaurus CUI : CL554334;

Details

Origin ID

C153210;

UMLS CUI

C4727093;

Currated CISMeF NLP mapping
- dezamizumab [MeSH Supplementary Concept]
- dezamizumab [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dezamizumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Serum Amyloid P-Component [NCIt concept]

Keyword's position in hierarchy(ies) :

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