Miridesap - CISMeF

Preferred Label : Miridesap;

NCIt synonyms : (2R)-1-[6-[(2R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid;

NCIt definition : A small molecule compound that depletes serum amyloid P component (SAP), with potential anti-amyloid activity. Upon injection, miridesap binds to circulating SAP, forming complexes that are rapidly cleared in the liver. SAP bound to amyloid deposits is in equilibrium with plasma SAP, and depletion of the latter should lead to the eventual removal of SAP from amyloid deposits as well. SAP is a universal component of amyloid deposits and contributes to the pathogenesis of amyloidosis.;

UNII : WO97N24A47;

InChIKey : HZLAWYIBLZNRFZ-VXGBXAGGSA-N;

CAS number : 224624-80-0;

Molecule name : CPHPC; GSK 2315698; GSK-2315698;

NCI Metathesaurus CUI : CL554333;

Details

Origin ID

C153209;

UMLS CUI

C4519306;

Automatic exact mappings (from CISMeF team)
- miridesap [MeSH Supplementary Concept]
- miridesap [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- miridesap [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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