Preferred Label : Olinciguat;
NCIt synonyms : Stimulator of Soluble Guanylate Cyclase IW-1701; sGC Stimulator IW-1701; Soluble Guanylate Cyclase Stimulator IW-1701;
NCIt definition : An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with potential
anti-inflammatory and vasodilating activities. Upon oral administration, olinciguat
targets, allosterically binds to and enhances the nitric oxide (NO)-dependent catalytic
activity of sGC. This enhances NO-sGC signaling and increases the formation of the
intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived
from guanosine triphosphate (GTP). This enhances NO/cGMP-mediated muscle relaxation,
suppresses leukocyte-endothelial interactions and promotes vascular anti-inflammatory
effects. The NO/sGC/cGMP signaling pathway plays an important role in vasodilation,
blood flow and inflammatory processes. sGC, a heme-containing cytoplasmic signaling
enzyme, catalyzes the formation of cGMP from GTP in response to NO binding to heme.;
UNII : PD5F4ZXD21;
InChIKey : YWQFJNWMWZMXRW-HXUWFJFHSA-N;
CAS number : 1628732-62-6;
Molecule name : IW-1701; IW 1701;
NCI Metathesaurus CUI : CL554401;
Origin ID : C153148;
UMLS CUI : C5139872;
Semantic type(s)
- concept_is_in_subset
